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NeuroNet: "Systematic Gene Identification and Functional Analyses in Common CNS Disorders"

Coordinator: Prof. Dr. Peter Propping

Project List:

Animal Models for Parkinson Disease

Identification of disease genes in Alzheimer disease

Identification of inhibitors and modulators of beta- and gamma-secretase

Identification of genes that regulate A-beta42 levels

Transgenic mouse models to study family forms of cerebral amyloid angiopathy

The role of APP-dependent gene expression in Alzheimer Disease

Identification of genes involved in neuroprotection of Alzheimer disease

Identification of Genetic Risk Factors of Parkinsons Disease

Deciphering molecular pathways of monogenic forms of Parkinson disease by cell culture and animal models

Identification and validation of Parkinson disease relevant genes by functional genomics in cell culture and animal models

Molecular mechanisms of differntial vulnerability of dopaminergic neurons in Parkinson Disease

Functional Analyses in genetic mouse model of Parkinson Disease

Population Based Assessment of Genetic Risk Factors for Parkinson Disease (PD)

Identification of disease genes in bipolar affective disorder

Phenotype refinement in bipolar affective disorder as a prerequisite for the identification of disease genes

Identification of novel candidate genes in unipolar depression

Recruitment of a population based cohort of patients with bipolar affective disorder

Animal models for the analysis of candidate genes in affective disorder

Identification of quantitative trait loci involved in alcohol drinking, stress-induced alcohol drinking and relapse

A phenotype-driven ENU mutagenesis screen for the identification of genes involved in alcohol drinking and relapse

Conditional genetic manipulation of candidate genes involved in alcohol drinking, stress- induced alcohol drinking and relapse: role of L-type voltage-gated calcium Channels

The role of CRH/CRH-R1 pathway in alcohol drinking

The role of GR pathway in alcohol drinking, stress-induced alcohol drinking and relapse

Validation in humans of genes involved in alcohol drinking, stress-induced alcohol drinking and relapse

Gene identification in idiopathic seizure disorders

Molecular genetic dissection of idiopathic generalized epilepsy

Functional Anaylsis of ion channel mutations causing idiopathic generalized epilepsies

Identification and functional analysis of genes in human idiopathic epilepsy

CNS hyperexcitability in mouse models affecting ion transport diseases

Pathophysiological mechanisms of neurodegeneration and epilepsy in a mouse model of KCNQ/M-channel deficiency