Cancer Network "Combating Cancer Through Integrated Functional Genomic Research"
Project List:
Identification and Characterisation of Antiapoptotic Genes involved in systemic therapy response
Functional analysis of new Wnt target genes identified by expression profiling
Organ Specificity of Colorectal Cancer Metastasis
Invasion-associated regulation of the transcriptome in colorectal cancer
Functional analysis of candidate genes involved in metastasis of colorectal cancer
Identification and characterization of genomic imbalances in acute myeloid leukemia (AML) with complex karyotype using microarray-CGH and gene expression analysis
Chromatin modifications and the transcriptome in acute myeloid leukemia
Comparative gene expression and proteomics profiling for classification of acute lymphoid leukemias and identification of abberant cellular signaling pathways
Molecular classification and risk stratification in patients with high risk childhood acute lymphoblastic leukemia based on gene expression profiling
Genomic analysis of resistant and relapsed childhood acute lymphblastic leukaemia to identify novel molecular risk factors of therapy failure
Establishment of quality criteria for pre-analytic changes in mRNA abundance and their assessment in thestudy of T-lymphoblastic leukaemia (T-ALL)
Bioinformatics, statistics and mathematical modeling in genomic reserach of leukemias
Identification of target genes of the nuclear oncoprotein AF4 involved in t(4;11) high risk acute leukemia
The genetic basis of sensitivity to the kinase inhibitor imatinib in Ph+ALL
Identification of target pathways of the CALM/AF10 fusion protein, which is found in AML and ALL
Proteomic Pathway Discovery in Acute Promyelocytic Leukemia
The significance of dysregulated homeobox gene expression in the pathogenesis of acute myeloid leukemia (AML) with FLT3-mutations
Genomic analysis of retinoic acid signalling in acute myeloid leukemia
Disruption of High-Molecular-Weight Complexes in Cancer by Intercalating Peptides
RNA interference as a tool for functional gene analysis and therapeutic gene silencing in cancer research
Identification and validation of histone methylation marks characteristic for the genome of cancer cells
Systematic analysis of microRNA expression in cancer development and metastasis
Functional yeast survival screen to identify new anti-apoptotic oncogenes in therapy-resistant tumors
Small-molecule inhibitors of cancer-relevant protein-protein interactions
Inducible mouse tumor models for in vivo imaging: Monitoring of tumor growth and therapy
Characterization of survival genes recovered from a functional gene trap screen in human breast cancer cells
Identification and characterization of T cell subsets with regulatory function in cancer
Animal tumor models for the evaluation of candidate gene function in tumor metastasis
Blocking the G2/M transition by targeting polo-like kinase 1 and Cdk1/cyclin B for tumor therapy
Identification of predictive and pharmacodynamic markers for cancer therapy with a novel HDAC inhibitor, Valproic Acid
Functional analysis of new Wnt target genes identified by expression profiling
Organ Specificity of Colorectal Cancer Metastasis
Invasion-associated regulation of the transcriptome in colorectal cancer
Functional analysis of candidate genes involved in metastasis of colorectal cancer
Identification and characterization of genomic imbalances in acute myeloid leukemia (AML) with complex karyotype using microarray-CGH and gene expression analysis
Chromatin modifications and the transcriptome in acute myeloid leukemia
Comparative gene expression and proteomics profiling for classification of acute lymphoid leukemias and identification of abberant cellular signaling pathways
Molecular classification and risk stratification in patients with high risk childhood acute lymphoblastic leukemia based on gene expression profiling
Genomic analysis of resistant and relapsed childhood acute lymphblastic leukaemia to identify novel molecular risk factors of therapy failure
Establishment of quality criteria for pre-analytic changes in mRNA abundance and their assessment in thestudy of T-lymphoblastic leukaemia (T-ALL)
Bioinformatics, statistics and mathematical modeling in genomic reserach of leukemias
Identification of target genes of the nuclear oncoprotein AF4 involved in t(4;11) high risk acute leukemia
The genetic basis of sensitivity to the kinase inhibitor imatinib in Ph+ALL
Identification of target pathways of the CALM/AF10 fusion protein, which is found in AML and ALL
Proteomic Pathway Discovery in Acute Promyelocytic Leukemia
The significance of dysregulated homeobox gene expression in the pathogenesis of acute myeloid leukemia (AML) with FLT3-mutations
Genomic analysis of retinoic acid signalling in acute myeloid leukemia
Disruption of High-Molecular-Weight Complexes in Cancer by Intercalating Peptides
RNA interference as a tool for functional gene analysis and therapeutic gene silencing in cancer research
Identification and validation of histone methylation marks characteristic for the genome of cancer cells
Systematic analysis of microRNA expression in cancer development and metastasis
Functional yeast survival screen to identify new anti-apoptotic oncogenes in therapy-resistant tumors
Small-molecule inhibitors of cancer-relevant protein-protein interactions
Inducible mouse tumor models for in vivo imaging: Monitoring of tumor growth and therapy
Characterization of survival genes recovered from a functional gene trap screen in human breast cancer cells
Identification and characterization of T cell subsets with regulatory function in cancer
Animal tumor models for the evaluation of candidate gene function in tumor metastasis
Blocking the G2/M transition by targeting polo-like kinase 1 and Cdk1/cyclin B for tumor therapy
Identification of predictive and pharmacodynamic markers for cancer therapy with a novel HDAC inhibitor, Valproic Acid