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Cancer Network "Combating Cancer Through Integrated Functional Genomic Research"

Coordinator: Prof. Dr. Walter Birchmeier

Project List:

Identification and Characterisation of Antiapoptotic Genes involved in systemic therapy response

Functional analysis of new Wnt target genes identified by expression profiling

Organ Specificity of Colorectal Cancer Metastasis

Invasion-associated regulation of the transcriptome in colorectal cancer

Functional analysis of candidate genes involved in metastasis of colorectal cancer

Identification and characterization of genomic imbalances in acute myeloid leukemia (AML) with complex karyotype using microarray-CGH and gene expression analysis

Chromatin modifications and the transcriptome in acute myeloid leukemia

Comparative gene expression and proteomics profiling for classification of acute lymphoid leukemias and identification of abberant cellular signaling pathways

Molecular classification and risk stratification in patients with high risk childhood acute lymphoblastic leukemia based on gene expression profiling

Genomic analysis of resistant and relapsed childhood acute lymphblastic leukaemia to identify novel molecular risk factors of therapy failure

Establishment of quality criteria for pre-analytic changes in mRNA abundance and their assessment in thestudy of T-lymphoblastic leukaemia (T-ALL)

Bioinformatics, statistics and mathematical modeling in genomic reserach of leukemias

Identification of target genes of the nuclear oncoprotein AF4 involved in t(4;11) high risk acute leukemia

The genetic basis of sensitivity to the kinase inhibitor imatinib in Ph+ALL

Identification of target pathways of the CALM/AF10 fusion protein, which is found in AML and ALL

Proteomic Pathway Discovery in Acute Promyelocytic Leukemia

The significance of dysregulated homeobox gene expression in the pathogenesis of acute myeloid leukemia (AML) with FLT3-mutations

Genomic analysis of retinoic acid signalling in acute myeloid leukemia

Disruption of High-Molecular-Weight Complexes in Cancer by Intercalating Peptides

RNA interference as a tool for functional gene analysis and therapeutic gene silencing in cancer research

Identification and validation of histone methylation marks characteristic for the genome of cancer cells

Systematic analysis of microRNA expression in cancer development and metastasis

Functional yeast survival screen to identify new anti-apoptotic oncogenes in therapy-resistant tumors

Small-molecule inhibitors of cancer-relevant protein-protein interactions

Inducible mouse tumor models for in vivo imaging: Monitoring of tumor growth and therapy

Characterization of survival genes recovered from a functional gene trap screen in human breast cancer cells

Identification and characterization of T cell subsets with regulatory function in cancer

Animal tumor models for the evaluation of candidate gene function in tumor metastasis

Blocking the G2/M transition by targeting polo-like kinase 1 and Cdk1/cyclin B for tumor therapy

Identification of predictive and pharmacodynamic markers for cancer therapy with a novel HDAC inhibitor, Valproic Acid