NGFN-Science: Management of shared chromosomal regions

Management of shared chromosomal regions

Due to the common linkage regions for many projects in this network, the positional cloning agendas focus on the same regions for different disorders. Thus, rather than to divide the molecular scientists according to phenotype, many network projects will jointly employ scientist to work on a certain chromosomal region. In our view, this has the following advantages:

it ensures the use of joint marker panels, which will cut genotyping costs
it centralizes the bioinformatic and transcript knowledge for a certain chomosomal region
It facilitates the cross-phenotyping approach (i. E. different inflammatory disorders with overlapping risk mutations)

The respective scientists for the subprojects that choose to be organised in this way, will be directly anchored and employed on the respective centralized molecular high-throughput platforms of each site.

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