The development of new technologies constitutes a major driving force of scientific progress. This statement is particularly relevant for disease related genome research. The second round of the NGFN program now includes a mechanism for research projects that are exploratory in nature.
The Exploratory Projects consist of studies that are geared towards the development of new methods and technologies with applications in human genome research. These include “proof of principle” projects that are related to the overall goals of NGFN with regard to Disease-Oriented Genome Networks and Systematic Methodological Platforms. The long term goal of the Exploratory Projects is to develop novel and innovative applications that can be adopted by and translated into the existing and established NGFN networks and platforms.
The nineteen Exploratory Projects can be grouped into two categories that are not mutually exclusive and in fact often show considerable overlap. One group consists of studies that are focused on methodological developments that are either advancements of existing technologies or completely novel in nature. The other group of projects is concerned with new ways for biomarker discovery relevant to the five disease areas that are part of the NGFN.
Explorative Projects
Summary:
Project List:
The role of serotonin receptor genes in the etiology of gastrointestinal disorders
Combining proteome-based technologies with epigenetics using renal cell carcinoma (RCC) as a model: Identification of RCC specific cancer antigenes for vaccine and antibody therapies
Synthetic antibodies for ChIP-chip in human cells
Whole cell model for the infection by the bacterial pathogen Pseudomonas aeruginosa– experiment and bioinformatics
Exploring the world of non-messenger RNAs: Rnomics meets Proteomics
Inferring genetic interactions from gene expression data
A novel link between genomics and functional proteomics with an impact on cancer immunotherapy of thefuture
Development of infrared scanning microprobe MALDI mass spectrometry for analytical imaging of tissue and molecular phenotyping of hypertension ("IR-SMALDI")
Genomic variability of host factors in the AIDS macaque model - role in resistance to and disease course of viral infections in humans and non human primates
Genetic etiology of human longevity
Microarray validation of cardiovascular risk factors
Brain endoscopy for the functional analysis of neuronal networks in vivo
Exploration of the 3D genome organization and its impact on gene expression during tumor development and aging with novel high throughput multicolour imaging technique
Identification of autoantigens as candidate markers for affective disorders
Peptide libraries on a chip
Determining the genes underlying the Williams-Beuren syndrome by generating allelic series of mutations using novel transposon approaches
Cellular and molecular signatures of human pluripotent stem cells
Near infrared nanocrystal-based quantitative protein arrays
Combining proteome-based technologies with epigenetics using renal cell carcinoma (RCC) as a model: Identification of RCC specific cancer antigenes for vaccine and antibody therapies
Synthetic antibodies for ChIP-chip in human cells
Whole cell model for the infection by the bacterial pathogen Pseudomonas aeruginosa– experiment and bioinformatics
Exploring the world of non-messenger RNAs: Rnomics meets Proteomics
Inferring genetic interactions from gene expression data
A novel link between genomics and functional proteomics with an impact on cancer immunotherapy of thefuture
Development of infrared scanning microprobe MALDI mass spectrometry for analytical imaging of tissue and molecular phenotyping of hypertension ("IR-SMALDI")
Genomic variability of host factors in the AIDS macaque model - role in resistance to and disease course of viral infections in humans and non human primates
Genetic etiology of human longevity
Microarray validation of cardiovascular risk factors
Brain endoscopy for the functional analysis of neuronal networks in vivo
Exploration of the 3D genome organization and its impact on gene expression during tumor development and aging with novel high throughput multicolour imaging technique
Identification of autoantigens as candidate markers for affective disorders
Peptide libraries on a chip
Determining the genes underlying the Williams-Beuren syndrome by generating allelic series of mutations using novel transposon approaches
Cellular and molecular signatures of human pluripotent stem cells
Near infrared nanocrystal-based quantitative protein arrays