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NeuroNet: “Obesity and Related Disorders”

Coordinator: Prof. Dr. Johannes Hebebrand

Project List:

Identification of candidate genes for human obesity

Genome wide linkage analysis using high density SNP arrays

High Throughput SNP Genotyping in Candidate Genes for Human Obesity

Identification of natural genetic variation liked to high fatness in selected mouse lines

Identification of candidate genes for human obesity in a mouse model of morbid, polygenic obesity

Hypothalamic gene expression in states of altered energy balance

Biostatistics, genetic epidemiological methods and data management

MC4R signalling within the hypothalaomic network of weight regulation

Altered melanocortin-4 and melanin-concentrating hormone receptor signalling in obesity

Confirmation of candidate genes for human obesity in large population based studies and independent type 2 diabetic family samples

Variation in candidate genes for obesity: Relative and attributable risk with obesity related diseases and association with quantitative traits of the metabolic syndrome

Polymorphism and frequency of obesity candidate genes in stroke patients

Potential polymorphisms of the VLDL receptor and other obesity candidate genes in patients with and without coronary artery disease

Neuroimaging of hunger and satiety and assessment of sympathetic nerve activity in carriers of a MC4-R gene mutation

Functional studies on the interaction between genetically and environmentally induced obesity

Metabolic phenotyping of mouse models for obesity

Searching for genes of body weight regulation on the left arm of body weight distribution: constitutional delay of growth and puberty, a paediatric model of leanness

Population genetics and molecular evolution of candidate genes for obesity