Infection and Inflammation: From Pathogen-induced Signatures to Therapeutic Target Genes
Project List:
Signatures and clinical validation: synovial tissues, tissue microarrays and tissue cells
Molecular characterization of host-virus interactions, towards novel cellular targets for anti-viral therapy
Identification of cellular targets in HSV-1 infected dendritic cells using functional genomics in order to establish new antiviral therapies
Identification of host cell factors involved in Hepatitis C virus replication as potential targets for HCV and flavivirus therapy
Cellular Pathways of infection and inflammation Role of TNF producing dendritic precursor cells in human models of sepsis
Prospective evaluation of clinical sepsis phenotypes by focussed gene expression profiling ("Sepchip") and association with genetic resistance factors
Animal models of sepsis and acute lung injury using Streptococcus pneumoniae
Determination of the septic host response via cell type-specific Toll-like receptor signalling
Staphylococcal sepsis - molecular basis, risk factors, and individual predisposition
Molecular, cellular and genetic basis of Streptococcus pyogenes-induced sepsis in mice
Identification of genes associated with resistance or susceptibility to acute gastrointestinal infection
Genetic determinants of host susceptibility, resistance, and disease outcome in acute and chronic enteric infections - Functional characterization of genes involved in innate immunity to and disease susceptibility für Yersinia enterocolitica
Transcriptome analysis to determine the primary site of immunity and the role of epithelial and hemapoetic cells for host susceptibility during infection with Heliobacter pylori
Identification of genetic determinants for host susceptibility and disease outcome in Heliobacter pylori infections
Ecological genomics of mucosal microbial communities associated with chronic inflamatory bowel disease
Murine gammaherpesvirus 68 (MHV-68): a mouse model for understanding innate immunity in gammaherpesvirus infection
Immune control of gamma-herpesvirus by innate immunity
CMV genes and innate immunity in vivo
Identification of human genetic variants mediating resistance to Plasmodium falciparum parasitaemia
Genetic association approach to identify endothelial receptors for Plasmodium falciparum
Association and linkage approaches to identify human genetic variants contributing to natural protection against pulmonary tuberculosis
Global transcriptome analysis of Pulmonary Lesions from Tuberculosis Patients
Identification and functional validation of genes associated with resistance or susceptibility to tuberculosis in a murine model of aerogenic M. tuberculosis infection
Clinical pattern assessment in Rheumatoid Arthritis and Spondyloarthropathies
Clinical validation by Custom Array
Signatures and clinical validation of synovial tissues and tissue cells
Inflammatory pathways in human disease: definition of specific and common mechanism of tissue response
Comparative expression profiling of T-cell subsets and monocytes and analysis of cell type specific gene function in mouse models of chronic inflammation
Development of new diagnostic tools for Rheumathoid Arthritis
TLR-signalling induced by bacterial and viral ligands / Microarray and Bioinformatics Core Unit
Bridging project: genetic basis of gender differences in type I IFN production from human plasmacytoid dendritic cells
Cross-talk between Toll-like receptors and Nuclear Hormone Receptors: Linking inflammation, immune suppression and artherosclerosis
Genetic determinants of innate immunity and immune modulation in nematode infections in mice
Data management
Bioinformatics
Therapeutics-induced gene signature in chronic rheumatoid diseases
Cytokine, pathogen, and therapeutic signatures of human and murine monocytes and T helper cells
Molecular characterization of host-virus interactions, towards novel cellular targets for anti-viral therapy
Identification of cellular targets in HSV-1 infected dendritic cells using functional genomics in order to establish new antiviral therapies
Identification of host cell factors involved in Hepatitis C virus replication as potential targets for HCV and flavivirus therapy
Cellular Pathways of infection and inflammation Role of TNF producing dendritic precursor cells in human models of sepsis
Prospective evaluation of clinical sepsis phenotypes by focussed gene expression profiling ("Sepchip") and association with genetic resistance factors
Animal models of sepsis and acute lung injury using Streptococcus pneumoniae
Determination of the septic host response via cell type-specific Toll-like receptor signalling
Staphylococcal sepsis - molecular basis, risk factors, and individual predisposition
Molecular, cellular and genetic basis of Streptococcus pyogenes-induced sepsis in mice
Identification of genes associated with resistance or susceptibility to acute gastrointestinal infection
Genetic determinants of host susceptibility, resistance, and disease outcome in acute and chronic enteric infections - Functional characterization of genes involved in innate immunity to and disease susceptibility für Yersinia enterocolitica
Transcriptome analysis to determine the primary site of immunity and the role of epithelial and hemapoetic cells for host susceptibility during infection with Heliobacter pylori
Identification of genetic determinants for host susceptibility and disease outcome in Heliobacter pylori infections
Ecological genomics of mucosal microbial communities associated with chronic inflamatory bowel disease
Murine gammaherpesvirus 68 (MHV-68): a mouse model for understanding innate immunity in gammaherpesvirus infection
Immune control of gamma-herpesvirus by innate immunity
CMV genes and innate immunity in vivo
Identification of human genetic variants mediating resistance to Plasmodium falciparum parasitaemia
Genetic association approach to identify endothelial receptors for Plasmodium falciparum
Association and linkage approaches to identify human genetic variants contributing to natural protection against pulmonary tuberculosis
Global transcriptome analysis of Pulmonary Lesions from Tuberculosis Patients
Identification and functional validation of genes associated with resistance or susceptibility to tuberculosis in a murine model of aerogenic M. tuberculosis infection
Clinical pattern assessment in Rheumatoid Arthritis and Spondyloarthropathies
Clinical validation by Custom Array
Signatures and clinical validation of synovial tissues and tissue cells
Inflammatory pathways in human disease: definition of specific and common mechanism of tissue response
Comparative expression profiling of T-cell subsets and monocytes and analysis of cell type specific gene function in mouse models of chronic inflammation
Development of new diagnostic tools for Rheumathoid Arthritis
TLR-signalling induced by bacterial and viral ligands / Microarray and Bioinformatics Core Unit
Bridging project: genetic basis of gender differences in type I IFN production from human plasmacytoid dendritic cells
Cross-talk between Toll-like receptors and Nuclear Hormone Receptors: Linking inflammation, immune suppression and artherosclerosis
Genetic determinants of innate immunity and immune modulation in nematode infections in mice
Data management
Bioinformatics
Therapeutics-induced gene signature in chronic rheumatoid diseases
Cytokine, pathogen, and therapeutic signatures of human and murine monocytes and T helper cells